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Evidence Based Medicine Research

Dr. Loomba and the fatty liver research team have expertise in conducting meta-analysis.

A meta-analysis is a technique in which two or more studies which have predetermined similar characteristics are mathematically combined to strengthen the accuracy of results. Studies chosen to be in a meta-analysis are usually similar in design and ideally would be high quality randomized controlled trials. The studies are pooled to identify the effect size, for which a weighted average may be an output for a specific intervention or question being studied.

Dr. Loomba has extensive experience performing meta-analyses. Expertise with this statistical technique is especially important for developing evidence based guidelines and better understanding the natural history and treatment efficacy.


  1. Loomba R, Wesley R, Pucino F, Liang TJ, Kleiner DE, Lavine JE. Placebo in nonalcoholic steatohepatitis: Insight into natural history and implications for future clinical trials. Clin Gastroenterol Hepatol 2008; 6(11): 1243-1248.
  2. Loomba R, Rowley AK, Wesley R, Smith KG, Liang TJ, Pucino F, Csako G. Hepatitis B immunoglobulin and lamivudine improve hepatitis B-related outcomes after liver transplantation: Meta-analysis. Clin Gastroenterol Hepatol 2008; 6(6): 696-700.
  3. Loomba R, Rowley A, Wesley R, Liang TJ, Hoofnagle JH, Pucino F, Csako G. Systematic review: The effect of preventive lamivudine on hepatitis B reactivation during chemotherapy. Ann Intern Med 2008; 148(7): 519-528.
  4. Loomba R, Wesley R, Bain A, Csako G, Pucino F. Role of fluoroquinolones in the primary prophylaxis of spontaneous bacterial peritonitis: Meta-analysis. Clin Gastroenterol Hepatol 2009; 7(4): 487-493.
  5. Boettcher E, Csako G, Pucino F, Wesley R, Loomba R. Meta-analysis: Pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2012; 35(1): 66-75.
  6. Poster presentation at AASLD meetings 2007, “Pre-emptive Lamivudine Reduces the Risk of Chemotherapy-Induced HBV-Related Morbidity and Mortality in HBsAg Positive Cancer Patients: A Meta-analysis.” Rohit Loomba, Ayana Rowley, Robert Wesley, T. Jake Liang, Jay H Hoofnagle, Frank Pucino, and Gyorgy Csako. Liver Diseases Branch, NIDDK, NIH, Bethesda, MD.
  7. Poster presentation at DDW meetings 2008, “Hepatitis B immunoglobulin and lamivudine reduce hepatitis B related morbidity and mortality post-liver transplantation: Meta-analysis.” Rohit Loomba, , Rowley A, Wesley R, Smith K, Liang TJ, Pucino F, and Csako G.