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Mayoral R, Valverde AM, Llorente C, González-Rodríguez A, Boscá L, Martín-Sanz P. Impairment of transforming growth factor beta signaling in caveolin-1- deficient hepatocytes: role in liver regeneration. J Biol Chem. 2010. Feb 5;285(6):3633-42. PMID: 19966340; PMCID: PMC2823504.
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Llorente C, Mayoral R, Flores JM, García-Palencia P, Cucarella C, Boscá L, Casado M, Martín-Sanz P. Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. Am J Pathol. 2011 Mar;178(3):1361-73. PMID: 21356386; PMCID: PMC3069875.
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Agra Andrieu N, Motiño O, Mayoral R, Llorente C, Fernández-Alvarez A, Boscá L, Casado M, Martín-Sanz P. Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells: Role in proliferation and apoptosis. PLoS One. 2012;7(11): e50935.
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Fernández-Alvarez A#, Llorente C#, Mayoral R, Agra N, Boscá L, Casado M, Martín-Sanz P. Evaluation of epigenetic modulation of Cyclooxygenase-2 as prognostic marker for hepatocellular carcinoma. Oncogenesis. 2012 Jul 9;1: e23. PMID: 23226427; PMCID: PMC3511388. #equal contribution.
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Llorente C, Mayoral R, Cucarella C, Grau C, Alvarez MS, Flores JM, García-Palencia P, Agra N, Castro-Sánchez L, Boscá L, Martín-Sanz P, Casado M. Progression of liver oncogenesis in the double transgenic mice c-myc/TGF-α is not enhanced by cyclooxygenase-2 expression. Prostaglandins Other Lipid Mediat. 2013 Oct; 106:106-15. PMID: 23579063.
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Castro-Sánchez L, Agra N, Llorente-Izquierdo C, Motiño O, Casado M, Boscá L, Martín-Sanz P. Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. Int J Biochem Cell Biol. 2013 Nov;45(11):2501-11. PMID: 23954207.
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Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Llorente C, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 Mar 5;4(5):378-91. PMID: 25973386; PMCID: PMC4421024.
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Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Cell Host Microbe. 2016 Feb 10;19(2):227-39. PMID: 26867181; PMCID: PMC4786170.
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Hartmann P, Seebauer CT, Mazagova M, Horvath A, Wang L, Llorente C, Varki NM, Brandl K, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1;310(5): G310-22. PMID: 26702135; PMCID: PMC4773827.
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Inamine T, Yang AM, Wang L, Lee KC, Llorente C, Schnabl B. Genetic Loss of Immunoglobulin A Does Not Influence Development of Alcoholic Steatohepatitis in Mice. Alcohol Clin Exp Res. 2016 Dec;40(12):2604-2613. PMID: 27739086; PMCID: PMC5133156.
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Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. Intestinal Fungi Contribute to Development of Alcoholic Liver Disease. J Clin Invest. 2017 Jun 30;127(7):2829-2841. PMID: 28530644; PMCID: PMC5490775.
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Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. Gastric Acid Suppression Promotes Alcoholic Liver Disease by Inducing Overgrowth of Intestinal Nat Commun. 2017 Oct 16;8(1):837. PMID: 29038503; PMCID: PMC5643518.
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Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, Lazaro R, Ansong C, Smith RD, Bataller R, Morgan T, Schnabl B, Tsukamoto H. Pyroptosis by caspase11/4-gardening-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018 May;67(5):1737-1753. PMID: 29108122; PMCID: PMC5906140.
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Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. 2018 Jun;67(6):2150-2166. PMID: 29159825; PMCID: PMC5962369.
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Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 2019 Jul 11; 130:4091-4109. PMID: 31295147; PMCID: PMC6763256.
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Duan Y#, Llorente C#, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia- Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. 2019 Nov;575(7783):505-511. PMID: 31723265; PMCID: PMC6872939. #equal contribution.
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Chu H, Duan Y, Lang S, Jiang L, Wang Y, Llorente C, Liu J, Mogavero S, Bosques-Padilla F, Abraldes JG, Vargas V, Tu XM, Yang L, Hou X, Hube B, Stärkel P, Schnabl B. The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. J Hepatol. 2020 Mar;72(3):391-400. PMID: 31606552; PMCID: PMC7031049.
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Zhou R, Llorente C, Cao J, Gao B, Duan Y, Jiang L, Wang Y, Kumar V, Stärkel P, Bode L, Fan X, Schnabl B. Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice. Alcohol Clin Exp Res. 2020 Sep;44(9):1842-1851. PMID: 32628772; PMCID: PMC7808344.
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Zhou R#, Llorente C#, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. Intestinal a-1-2-fucosylation contributes to obesity and steatohepatitis in mice. Cell Mol Gastroenterol 2021 Feb 22;12(1):293-320. PMID: 33631374; PMCID: PMC8166943. #equal contribution.
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Cabré N, Duan Y, Llorente C, Conrad M, Stern P, Yamashita D, Schnabl B. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells 2021; 10:1496. PMID: 34198609; PMCID: PMC8232222.
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Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. CRIg on liver macrophages clear pathobionts and protects against alcoholic liver disease. Nat Commun. 2021; 2(1):7172. PMID: 34887405; PMCID: PMC8660815.
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Murillo-Saich J, Coras R, Meyer R, Llorente C, Lane NE, Guma M. Synovial tissue metabolomic profiling reveals biomarkers of synovial inflammation in patients with osteoarthritis. Osteoarthr Cartil Open. 2022 Jul 9;4(3):100295. doi: 10.1016/j.ocarto.2022.100295. eCollection 2022 Sep. MID: 36474936; PMCID: PMC9718344.
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Zeng S, Hartmann P, Park M, Duan Y, Lang S, Llorente C, Wang Y, Cabré N, Fouts DE, Bacher P, Jung WH, Stärkel P, Schnabl B. Malassezia restricta promotes alcohol-induced liver injury. Hepatol Commun. 2023 Jan 27;7(2):e0029. PMID: 36706195; PMCID: PMC9988279.
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Cabré N, Hartmann P, Llorente C, Kouno T, Wang Y, Zeng S, Kim HY, Zhang X, Kisseleva T, Iyer S, Kudumala S, Schnabl B. IgY antibodies against cytolysin reduce ethanol-induced liver disease in mice. 2023 Jul 1;78(1):295-306. PMID: 36811393; PMCID: PMC10293100. PMID: 36811393; PMCID: PMC10293100.
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Hsu CL, Wang Y, Duan Y, Chu H, Hartmann P, Llorente C, Zhou R, Schnabl B. Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease. Dig Dis Sci. Jul;68(7):3059-3069. PMID: 36807831; PMCID: PMC10313731.
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Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice. Alcohol Clin Exp Res. 2023 May;47(5):856-867. PMID: 36871955; PMCID: PMC10795770.
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Fuster D, Llorente C, Garcia-Calvo X, Bolao F, Zuluaga P, Hernández-Rubio A, Casado-Carbajo J, Leis A, Muga R. Fungal plasma biomarkers in patients admitted for inpatient treatment of alcohol use disorder. Clin Exp Res (Hoboken). 2023 Aug;47(8):1582-1589. PMID: 37364901; PMCID: PMC10984271.
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Hernandez J, Llorente C; Ma S, Saptarshi S, Ghosh P, Schnabl B, Huang W J.M. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Science Alliance. 2023 Sep 4;6(11):e202302026. PMID: 37666668; PMCID: PMC10477432.
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Llorente C. Isolation of Myenteric and Submucosal Plexus from Mouse Gastrointestinal Tract and Subsequent Co-Culture with Small Intestinal Organoids. Cells. 2024 May 10;13(10):815. PMID: 38786037; PMCID: PMC11120043.
- Zhang P, Liu J, Su H, Kim J, Gu L, Shalapour S, Bandyopadhyay G, Zeng S, Llorente C, Vo N, Lee A, Tsaur I, Zhu M, Olefsky J.M., Schnabl B, Soroosh P, Karin M. IL-22 resolves NAFLD via STAT3 dependent restoration of diet perturbed intestinal homeostasis. 2023. Cell Metabolism. https://doi.org/10.1016/j.cmet.2024.08.012. [Accepted].